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Considerations for Exposure to Diazinon and Chlorpyrifos - page 42 / 49

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The Bottom Line

PON1

L55M

Q192R

W194X

(premature stop)

124 missplice

(low activity)

P90L

(low activity)

-108CT

-162GA

A lot of things can happen between the gene encoding PON1 and the final PON1 protein product in the plasma.  The high throughput two substrate assay provides the determination of the end result of all of the processes from transcription to the HDL particle and is the method of choice for studies of genetic variation of PON1.  

Functional two-substrate analysis

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