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Considerations for Exposure to Diazinon and Chlorpyrifos - page 43 / 49

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Research Needs

More Data are needed on oxon content of residues (completely ignored in safety testing)

Data are needed on residue ratios (DZO/DZS) and persistence over time and along product line (wool processing)

Development of realistic (DZO/DZS) exposure models including genetic variability - iterate humanized mouse data with PBPK/PD models

Data are needed on DZO/DZS effects on developing fetus

Identify longer-term biomarkers of exposure

Better endpoints of exposure than ChE inhibition (microarray analysis of effects on gene expression in different tissues/organs)

Effects of DZS exposure on reproductive health

Identification of other targets of DZS/DZO

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