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Considerations for Exposure to Diazinon and Chlorpyrifos - page 5 / 49

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Problems with Safety Tests

Most if not all safety tests were carried out with highly pure parent compounds (usuallly >99%).

Exposures may contain a significant percentage of highly toxic oxon form of the OP.

The oxon form is a much more potent inhibitor of cholinesterase than parent compound

The genetic and developmental variability of sensitivity to the oxon component is significant

Thioates are suicide substrates for P450s

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