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lation of route and medium of curcumin administration, blocking of metabolic pathways by concomitant administra- tion with other agents, and structural modifications are the main strategies now being explored in attempts to improve the bioavailability of curcumin. Attempts at enhanced in Vitro and in ViVo efficacies of curcumin through structural modifications of the molecule and/or new formulations have been recently reported. However, the limited literature evidence devoted to show improvements in curcumin bio- availability reveals that the curcumin bioavailability enhance- ment has not gained significant attention. Yet, novel delivery

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MOLECULAR PHARMACEUTICS VOL. 4, NO. 6

Anand et al.

strategies including those of nanoparticles, liposomes, and defined phospholipid complexes offer significant promise and are worthy of further exploration in attempts to enhance the bioavailability, medicinal value, and application of this interesting molecule from Mother Nature.

Acknowledgment. Dr. Aggarwal is the Ransom Horne, Jr., Professor of Cancer Research. This work was supported by grants from the Clayton Foundation for Research.

MP700113R

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